Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP

The high-density gastroretentive dosage forms was made a theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. used sodium alginate and PVP K30, where 1st formula ratio of alginate: K30 (18.75%: 5%), 2nd 2, 5%) 3th (12.5%: 2.5%). third were evaluated weight uniformity test, size hardness drug content vitro release as well determination kinetics release. result showed weights ranges 250.12mg-250.70mg, 0.81cm for diameter tablet 0.42cm-0.44cm thick tablet, test from 90N-180N. Results obtained 106.965% 1st, is 127.625% 115.976%. Release kinetic profiles show Higuchi equation first-order equation. By these formula, considered best views kinetics.